If a hypersensitivity reaction is suspected, discontinue JANUVIA, assess for other potential causes for the event, and institute alternative treatment for diabetes. Angioedema has also been reported with other DPP-4 inhibitors. There have been postmarketing reports of severe and disabling arthralgia in patients taking DPP-4 inhibitors. The time to onset of symptoms following initiation of drug therapy varied from 1 day to years.
Patients experienced relief of symptoms upon discontinuation of the medication. A subset of patients experienced a recurrence of symptoms when restarting the same drug or a different DPP-4 inhibitor.
Consider DPP-4 inhibitors as a possible cause for severe joint pain and discontinue drug if appropriate. Postmarketing cases of bullous pemphigoid requiring hospitalization have been reported with DPP-4 inhibitor use. In reported cases, patients typically recovered with topical or systemic immunosuppressive treatment and discontinuation of the DPP-4 inhibitor.
If bullous pemphigoid is suspected, JANUVIA should be discontinued and referral to a dermatologist should be considered for diagnosis and appropriate treatment. The Medication Guide also is available. Effect of renal insufficiency on the pharmacokinetics of sitagliptin, a dipeptidyl peptidase-4 inhibitor. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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The singer and actor shares why using the "time in range" metric to help manage his type 1 diabetes has been a "life-changing" discovery. The risk factors for type 2 diabetes are complex and range from genetic to environmental to lifestyle choices. Learn more. My diagnosis was a wake-up call. It was time to take care of my health.
Learn more about its symptoms, causes, and treatment. I learned that the best type 2 diabetes diet is the one that works for you. Health Conditions Discover Plan Connect. Medically reviewed by Dena Westphalen, Pharm. Frequently asked questions. What if I miss a dose? What factors can affect my dosage?
How is Januvia taken? What should be done in case of overdose? What should I ask my doctor? Ask a pharmacist. Type 2 Diabetes and Oral Health.
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty. This medicine is for you. Never give it to other people even if their condition appears to be the same as yours. Do not keep out-of-date or unwanted medicines.
Take them to your local pharmacy which will dispose of them for you. Dated May Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. Egton Medical Information Systems Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy.
Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions. Take sitagliptin tablets once a day. Remember to follow any advice you have been given about your diet.
The most common side-effects are feeling sick nausea , headache, and nose or throat infections. In this article About sitagliptin Before taking sitagliptin How to take sitagliptin Getting the most from your treatment Can sitagliptin cause problems? How to store sitagliptin Important information about all medicines.
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